(Paper) Sample Paper For Medical Exams : Solved Version With Few Explanations (Pg- 9)
Paper : Sample Paper For Medical Exams : Solved Version With Few Explanations
Page -9
201. A 1-moth old baby presents with frequent vomiting and failure to thrive. There are features of moderate dehydrtion. Blood sodium is 122mEa/l and potassium is 6.1 mEq/l. The most likely diagnosis is:
1. Gitelman syndrome.
2. Bartter syndrome.
3. 21-hydroxylase deficiency.
4. 11-b hydroxylase deficiency.
Ans.3
202. A male child of 15 years, with a mental age of 9 years has an IQ of:
1. 50
2. 60
3. 70
4. 80
Ans. 2
203. The most appropriate drug used for chelation therapy in beta thalassemia major is:
1. Oral desferroxamine.
2. Oral deferiprone.
3. Intramuscular EDTA.
4. Oral Succimer.
Ans.2
204. Which endocrine disorder is associated with epiphyseal dysgenesis?
1. Hypothyrodism.
2. Cushings syndrome.
3. Addison's disease.
4. Hypoparathyroidism.
Ans. 1
205. An albino girls gets married to a normal boy. What are the chances of their having an affected child and what are the chances of their children being carriers?
1. None affected, all carriers.
2. All normal.
3. 50% carriers.
4. 50% affected. 50% carriers.
Ans. 1
206. A 63-year-old man presented with massive splenomegaly, lymphadenopathy and a total leucocyte count of 17000 per mm3. The flowcytometery showed CD 19 positive, CD5 positive, DC 23 negative, monoclonal Bcells with bright kappa positivity comprising 80% of the peripheral blood lymphoid cells. The most likely diagnosis is:
1. Mantle cell lymphoma.
2. Splenic lymphoma with villous lymphocytes.
3. Follicular lymphoma.
4. Hairy cellleukemia.
Ans.1
207. Memory T cells can be identified by using the following marker:
1. CD45 RA.
2. CD45 RB.
3. CD45RC.
4. CD45RO.
Ans. 4
208. All of the following statements about NK cells are true. except:
1. They are derived from large granular cells.
2. They comprise about 5% of human peripheral lymphoid cells.
3. They are MHC restricted cytotoxic cells
4. They express lgG Fc receptors.
Ans. 3
209. Which of the following increases the susceptibility to coronary artery disease:
1. Type V hyperlipoproteinaemia.
2. Von will Brandt’s disease.
3. Nephritic syndrome.
4. Systemic lupus erythematosus.
Ans.1
210. MHC class 3 Genes Encode;
1. Complement Component C3
2. Tumor necrosis factor.
3. Interleukin 2.
4. Beta 2 microglobulin.
Ans. 2 [ Paniker 5th ed, page 120 says that only C3 convertase is derived from HLA class III , also derived is TNF. BUT ROBBINs 5th ed page 175 figure 6-4 clearly tells on 6th chromosome TNF is derived from cytokines gene, and all complement from MHC genes.]
211. The HLA class 3 rejection genes are important elements in :
1. Transplant rejection phenomenon.
2. Governing susceptibility of autoimmune diseases.
3. Immune surveillance.
4. Antigen presentaion and elimination.
Ans 2
212. Gluten sensitve enteropthy is most strongly associated with:
1. HLA-DQ2
2. HLA-DQ4
3. HLA-DQ3
4. Blood group ‘B’
Ans. 1
213. Most sensitve and specific test ofr diagnosis of iron efficiency is :
1. Serum iron levels.
2. Serum ferrition levels.
3. Serum transferring receptor population :
4. Transferrin saturation.
Ans. 2
214. All the statrment about lactoferrin are true, except:
1. It is present in secondary granules of neutrophil
2. It is present in exocrine secretios of body.
3. It has great affinity for iron.
4. It transports iron for erythropoiesis.
Ans.4
215. All of the following are poor prognostic factors for acute myeloid leukemias, except:
1. Age more than 60 years.
2. Leucocyte count more than 1,000,000/ul.
3. Secondary leukenias.
4. presence of t (8:21)
Ans.4
216. Leukoelrythroblastic picture may be seen in all of the following except:
1. Myelofibrois.
2. Metastatic careinoma.
3. Gaucher’s disease.
4. Thalassemia.
Ans.4
217. Vortex vein invasion is commonly seen in:
1. Retinoblastoma.
2. Malignant melanoma.
3. Optic nerve gliomas.
4. Medullo-epitheliomas.
Ans. 2 (or 1?)
[ Web Ref Link
for Malignant Melanoma
For Choice 1 See SK Basak pg 237.
It occurs in both but most commonly?]
218. Hereditary retinoblastomas develop the following choromosomal deletion:
1. 13q 14
2. 13p14
3. 14p13
4. 14q13
Ans.1
219. All of the following are useful intravenous therapy for hypertensicve emergencies except:
1. Fenoldopam.
2. Urapidil
3. Enalpril
4. Nifedipine.
Ans. 4
220. Porphobilinogen in urine produces pink color with:
1. Fouchet’s reagent.
2. Benedict’s reagent.
3. Sodium nitropruside.
4. Ehrlich’s aldehyde reagent.
Ans. 4 Dr Bruno [ This is also known as Watson-Schwartz reaction. It employs
the use of Ehrlich's Reagent, paradimethylaminobenzaldehyde. The mixture of
urine and reagent produce a color which, if extracts into chloroform, confirms
the presence of urobilinogen.
Interpretations of this test are
i. If positive in Varigate Porphyria - Acute attack as Watson-Schwartz reaction
is negative in quiescent VP.
ii If positive in Acute intermittant porphyria - Acute attack not confirmed as
this test is also positive in remission phase. Absolute confirmation of the
presence of an acute attack can only be gained by performing accurate ALA and
PBG quantitation in the laboratory and comparing them with previous values for
the same patient. Therefore it is suggested that any patient known to have
porphyria and who shows a positive Watson-Schwartz reaction, and has compatible
clinical features, must be considered to be suffering from the acute attack.
Web Reference: 1) http://web.uct.ac.za~~/porphyria
notes/acute attack management.htm
2) VH
: Virtual Hospital Site Link Last Paragraph.]
221. Cardiac output measured by thermodilution technique is unreliable in all of the following situations except:
1. Ventricular septal defect.
2. Tricuspid regurgitation.
3. Low cardiac output
4. Pumonary regugitation
Ans.4
222. Exercise testing is absolutely contraindicated in which one week following :
1.One week following myocardial infarction
2. Unstable angina.
3. Aortic stenosis
4. peripheral vascular dicase.
Ans. 3 CMDT 2003 pg 338 Mentions that Aortic stenosis is a contraindication. It also says that patients with pain at rest / pain on minimal excercise should not be tested. But Davidson, Harrison mention that Patients with unstable angina / MI more than 5 days are candidites for stress testing. [With some inputs from Bruno]
223. Osteomatacia is associated with:
1. Decrease in osteoid volume.
2. Derease in osteoid surface.
3. increase in osteoid maturiaton time
4. Increase in mineral apposition rate.
Ans.3
224. A nineteen year old female with short stature wide spread nipples and primary amenorrhoea most likely has a karyotype of :
1. 47, XX +18
2. 46,XXY
3. 47,XXY
4. 45X.
Ans. 4
225. Which of the following procedures are wsed as routine technique for karyotyping using light microscopy ?
1. C- banding
2. G- banding
3. Q- banding
4. B-rd V- staning
Ans.2
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