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(Model Test Paper) PG Medical Entrance Examination Model Paper For (Biochemistry)

Posted January 27th, 2009 by guru

Test Paper :  PG Medical Entrance Examination Model Paper For (Biochemistry)

Question 1: Mathemtical representation of Conserved region known as


    1. Motif
    2. Profile
    3. Pattern
    4. Module
    5.
Correct Answer: 1.


Question 2: The generation of messenger RNA expression profiles is referred as

    1. transcription
    2. trasncriptomics
    3. Genomics
    4. RNAsyn
    5.
Correct Answer: 2.


Question 3: Which is the literature database of the following:

    1. GEO
    2. PubMed
    3. EST
    4. MMDB
    5.
Correct Answer: 2.


Question 4: All of the following are carbohydrates EXCEPT:

    1. starch
    2. glycogen
    3. chitin
    4. cholestrol
    5.
Correct Answer: 4.


Question 5: Books available in the following site

    1. EMBL
    2. NCBI
    3. RCSB
    4. PIR
    5.
Correct Answer: 2.


Question 6: Lipinski s rule states that the drug has not more than ________ hydrogen bond donors.

    1. 2
    2. 3
    3. 4
    4. 5
    5.
Correct Answer: 2.


Question 7: Which type of BLOSUM matrix mostly used

    1. BLOSUM62
    2. BLOSUM72
    3. BLOSUM82
    4. BLOSUM92
    5.
Correct Answer: 1.


Question 8: ________________ is 3D protein viewer.

    1. Marvin space
    2. Rasmol
    3. Swiss PDB Viewer
    4. All
    5.
Correct Answer: 4.


Question 9: Phylogenetic analysis tools include

    1. Phylip
    2. PAUP
    3. Both
    4. none
    5.
Correct Answer: 4.


Question 10: In how many centres clinical trials should be carried out

    1. 1-2
    2. 2-3
    3. 3-4
    4. 4-5
    5.
Correct Answer: 3.


Question 11: How many SNPs present in Human Genome reported by HGP?

    1. 2.2 million
    2. 2.1 million
    3. 3.3 billion
    4. 4.2 billion
    5.
Correct Answer: 2.


Question 12: tRNA genes are identified by using.

    1. tRNAscan
    2. Translate tool
    3. Chime
    4. Hex
    5.
Correct Answer: 1.


Question 13: The main enzyme responsible for activation of xenobiotics is

    1. Cytochrome P-450
    2. Glutathione S-transferase
    3. NADPH cytochrome P-450-reductase
    4. Glucuronyl transferase
    5.
Correct Answer: 3.


Question 14: Name the protein sequence database

    1. Uniprot
    2. PIR
    3. Swiss-prot
    4. all of the above
    5.
Correct Answer: 4.


Question 15: Which sequencing method efficiently helpful for Human Genome Project?

    1. Sanger Method
    2. Maxm-Gilbert method
    3. Whole Genome Shotgun
    4. None
    5.
Correct Answer: 3.


Question 16: Translate tool at ExPASy provides, how many numbers of frames of frames of translation

    1. 3
    2. 4
    3. 5
    4. 6
    5.
Correct Answer: 4.


Question 17: Pyrite oxidation thesis on ground water pollution mainly describes about____ poisoning of ground water

    1. mercury
    2. arsenic
    3. aluminum
    4. copper
    5.
Correct Answer: 2.


Question 18: Leads means

    1. Chemical
    2. drug
    3. Possible drug
    4. All
    5.
Correct Answer: 4.


Question 19: Porphobilinogen in urine produces pink color with

    1. Fouchet’s reagent
    2. Benedict’s reagent
    3. Sodium nitroprusside
    4. Ehrlich’s aldehyde reagent
    5.
Correct Answer: 4.


Question 20: What is the database used in ensembl

    1. Oracle
    2. MS-Access
    3. Mysql
    4. all of the above
    5.
Correct Answer: 3.


Question 21: Which of the following aminoacids is associated with increased risk of Myocardial infarction

    1. Methionine
    2. Homocysteine
    3. Ornithine
    4. Valine
    5.
Correct Answer: 2.


Question 22: Which of the following is used in PET scans?

    1. uranium
    2. ions
    3. isotopes
    4. steroids
    5.
Correct Answer: 3.


Question 23: Macrophages in the walls of arteries have receptors for

    1. Oxidised IDL
    2. Oxidased LDL
    3. LDL
    4. IDL
    5.
Correct Answer: 2.


Question 24: A traditional chemist can synthesize _____________ compounds per year.

    1. 100-200
    2. 200-300
    3. 300-400
    4. 400-500
    5.
Correct Answer: 1.


Question 25: Clustalw used for

    1. Structure prediction
    2. Motif analysis
    3. Multiple sequence alignment
    4. None
    5.
Correct Answer: 3.


Question 26: When first completed report of Human Genome was released?

    1. 2000
    2. 2001
    3. 2002
    4. 2003
    5.
Correct Answer: 1.


Question 27: Name the software for Natural Language Processing

    1. openNLP
    2. SPSS
    3. SAS
    4. None
    5.
Correct Answer: 1.


Question 28: Which type of PAM matrix mostly used

    1. PAM 100
    2. PAM150
    3. PAM200
    4. PAM250
    5.
Correct Answer: 3.


Question 29: Large genome annotated database is

    1. Genbank
    2. Uniprot
    3. Ensembl
    4. MMDB
    5.
Correct Answer: 3.


Question 30: ____________ tool used for Pattern construction.

    1. Pratt
    2. Patcons
    3. Both
    4. None
    5.
Correct Answer: 3.


Question 31: What is the percentage of Human Genome sequenced properly?

    1. 50%
    2. 60%
    3. 94%
    4. 84%
    5.
Correct Answer: 3.


Question 32: Secondary structure predicted by

    1. GOR
    2. COILS
    3. Nnpred
    4. All
    5.
Correct Answer: 2.


Question 33: Server which predicts the presence and location of signal peptide cleavage sites is

    1. Sigpred
    2. SignalI
    3. SignalP
    4. Sigprepred
    5.
Correct Answer: 3.


Question 34: Pharmacophore term defined by

    1. Pauling
    2. Ehrlich
    3. Koshland
    4. Watson
    5.
Correct Answer: 3.


Question 35: _______ - is an interconnected group of artificial neurons and processes information using a connectionist approach to computation.

    1. Neural network
    2. Network
    3. Internetwork
    4. Intranetwork
    5.
Correct Answer: 1.


Question 36: In the following acts as secondary pollutant.

    1. Br2
    2. Cl2
    3. NO2
    4. HNO3
    5.
Correct Answer: 4.


Question 37: Which is the identifier in Genbank

    1. Entry Name
    2. Locus
    3. both
    4. None
    5.
Correct Answer: 2.


Question 38: When Human Genome Project formally proposed?

    1. 1975
    2. 1985
    3. 1995
    4. 2005
    5.
Correct Answer: 2.


Question 39: Characters are homologous with conserved function known as

    1. Analogous
    2. Orthologous
    3. Paralogous
    4. Xenologous
    5.
Correct Answer: 1.


Question 40: ________________ is a database that provides comprehensive information on mammalian microRNAs.

    1. Argonaute
    2. RDP
    3. tRNADB
    4. None
    5.
Correct Answer: 1.


Question 41: ____is single largest source for carbon monoxide

    1. Volcanoes eruptions
    2. Dust storm
    3. Cigarette smoke
    4. Vehicular exhaust
    5.
Correct Answer: 3.


Question 42: In CATH, T  represents:

    1. Torsion
    2. Topology
    3. Target
    4. TRNA
    5.
Correct Answer: 2.


Question 43: ___is the second layer of the atmosphere.

    1. Stratosphere
    2. thermosphere
    3. Mesosphere
    4. Troposphere
    5.
Correct Answer: 4.


Question 44: When Human genome sequencing initiated?

    1. 1996
    2. 1997
    3. 1998
    4. 1999
    5.
Correct Answer: 4.


Question 45: Phenylalanine is the precursor of all the following except

    1. Tyrosine
    2. Epinephrine
    3. Thyroxine
    4. Melatonin
    5.
Correct Answer: 4.


Question 46: The protein rich inbasic amino acids, which functions in the packaging of DNA in chromosomes, is

    1. Histone
    2. Collagen
    3. Elastin
    4. Hyaluronic acid binding protein
    5.
Correct Answer: 1.


Question 47: The gas which produces systemic toxicity without causing local irritation is

    1. Ammonium
    2. Carbon monoxide
    3. Hydrocyanic acid
    4. Sulfur dioxide
    5.
Correct Answer: 2.


Question 48: Competitive inhibition is characterized by

    1. Increased Km and V Max is same
    2. Increased Vmax and Km remains constant
    3. Increased Km and increased Vmax
    4. Decreased Km and increased Vmax
    5.
Correct Answer: 1.


Question 49: The primary role of chaperones is to help in

    1. Protein synthesis
    2. Protein degradation
    3. Protein denaturation
    4. Protein folding
    5.
Correct Answer: 4.


Question 50: BioEdit used for

    1. Similarity studies
    2. Structure Prediction
    3. Profile search
    4. Motif search
    5.
Correct Answer: 2.


Question 51: When Human Genome Project work was officially started?

    1. 1970
    2. 1980
    3. 1990
    4. 2000
    5.
Correct Answer: 3.


Question 52: How many species support provided by Ensembl as by 47th release on 2007

    1. 55
    2. 45
    3. 35
    4. 25
    5.
Correct Answer: 3.


Question 53: Entropy in a biological system does not increase because

    1. It is an open system
    2. It is a closed system
    3. It is governed by vitalism
    4. It is not related to thermodynamics
    5.
Correct Answer: 1.


Question 54: Consider the following statements: 1. Caffeine, a constituent of tea and coffee is a diuretic. 2. Citric acid is used in soft drinks. 3. Ascorbic acid is essential for the formation of bones and teeth. 4. Citric acid is a good substitution for ascorbic acid in our nutrition. Which of the statements given above are correct?

    1. 1 and 2, only
    2. 1, 2 and 3, only
    3. 3 and , only
    4. 1, 2, 3 and 4
    5.
Correct Answer: 1.


Question 55: The conversion of an optically pure isomer (enantiomer) into a mixture of equal amounts of both dextro and levo forms is called as:

    1. Polymerization
    2. Stereoisomerization.
    3. Racemization
    4. Fractionation
    5.
Correct Answer: 3.


Question 56: Gene prediction tool at NCBI is

    1. Genscan
    2. Genefinder
    3. ORF finder
    4. All
    5.
Correct Answer: 2.


Question 57: The cohesion of water is caused by:

    1. ionic bonds
    2. hydrophobic compounds
    3. hydrogen bonds
    4. covalent bonds
    5.
Correct Answer: 3.


Question 58: Elasticity of the corneal layer of skin is due to the presence of

    1. Histidine
    2. Cysteine
    3. Keratin
    4. Lysine
    5.
Correct Answer: 2.


Question 59: How many groups involved in HGP?

    1. 10
    2. 20
    3. 30
    4. 40
    5.
Correct Answer: 2.


Question 60: Which of the following is not a post transcriptional modification of RNA

    1. Splicing
    2. 5' Capping
    3. 3' polyadenylation
    4. Glycosylation
    5.
Correct Answer: 4.


Question 61: The part of enzyme bound to the protein part by a covalent bond is called

    1. Holoenzyme
    2. Cofactor
    3. Prosthetic group
    4. Apoenzyme
    5.
Correct Answer: 3.


Question 62: How many ways Denovo designing might be used for drug designing?

    1. 1
    2. 2
    3. 3
    4. 4
    5.
Correct Answer: 1.


Question 63: Which pathway database based on reference pathway maps:

    1. Metacyc
    2. Ecocyc
    3. KEGG pathway
    4. UM-BBD
    5.
Correct Answer: 1.


Question 64: Soil with equal mixture of clay, sand. Silt and humus is called

    1. Gloom
    2. Loams
    3. Lombs
    4. Roam
    5.
Correct Answer: 2.


Question 65: Source of the nitrogen in urea cycle

    1. aspartate and ammonia
    2. glutamate and ammonia
    3. argenase and ammonia
    4.
    5.
Correct Answer: 1.


Question 66: Before analyzing sequence, it can be converted into different formats using

    1. Formcon
    2. Readseq
    3. Readcon
    4. Confor
    5.
Correct Answer: 4.


Question 67: 3DPSSM predicts tertiary structure through

    1. Homology
    2. Threading
    3. Abinitio
    4. All
    5.
Correct Answer: 3.


Question 68: Clinical trials for Vaccine contains _________ number of phases.

    1. 1
    2. 2
    3. 3
    4. 4
    5.
Correct Answer: 3.


Question 69: The buffering capacity of a buffer is maximum at pH equal to

    1. 0.5pKa
    2. pKa
    3. pKa+1
    4. 2pKa
    5.
Correct Answer: 2.


Question 70: Tool used for Local alignment is

    1. BLAST
    2. ClustalW
    3. ORF Finder
    4. Genscan
    5.
Correct Answer: 3.


Question 71: Pair-wise alignment include

    1. Local
    2. Global
    3. Both
    4. None
    5.
Correct Answer: 2.


Question 72: Which produces the abinitio prediction of protein function from sequence.

    1. ProtFun
    2. PFP Server
    3. Pratt
    4. none
    5.
Correct Answer: 3.


Question 73: Which alignment might be useful for phylogenetic analysis

    1. Pair-wise
    2. Multiple
    3. Both
    4. none
    5.
Correct Answer: 1.


Question 74: Designing a drug molecule atom by atom against a receptor or target known as

    1. Denovo
    2. QSAR
    3. Pharmacophore mapping
    4. Docking
    5.
Correct Answer: 1.


Question 75: It is a freely accessible database of protein and genetic interactions

    1. GOD
    2. MOTIF
    3. BIOGRID
    4. None
    5.
Correct Answer: 3.


Question 76: An enzyme involved in the catabolism of fructose to pyruvate in the liver is

    1. Glyceraldehyde-3-phosphate Dehydrogenase
    2. Phosphoglucomutase
    3. Lactate-dehydrogenase
    4. Glucokinase
    5.
Correct Answer: 1.


Question 77: Apo B 48 and Apo B 100 differ due to

    1. RNA splicing
    2. Apo B gene
    3. Chromosomal loci
    4. Gene rearrangement
    5.
Correct Answer: 1.


Question 78: One of the following not comes under classification of databases on the basis of type of data:

    1. Nucleotide sequence
    2. Protein sequence
    3. Primary db
    4. Metabolic pathway
    5.
Correct Answer: 3.


Question 79: In oxidative phosphorylation, the ATP production and respiratory chain are linked by

    1. Chemical methods
    2. Physical methods
    3. Chemiosmotic methods
    4. Conformational changes
    5.
Correct Answer: 3.


Question 80: The collagen triple helix structure is not found in

    1. Cytoplasm
    2. Golgi apparatus
    3. Lumen of endoplasmic reticulum
    4. Intracellular vesicles
    5.
Correct Answer: 1.


Question 81: In Collagen synthesis, hydroxyproline is converted to

    1. Proline
    2. Lysine
    3. Hydroxy lysine
    4. None of the above
    5.
Correct Answer: 1.


Question 82: The study of the effects of drugs on tissues and organs is called as

    1. Pharmacodynamcis
    2. Pharmacokinetics
    3. Pharmacophore
    4. All
    5.
Correct Answer: 4.


Question 83: KEGG is an structural database

    1. True
    2. False
    3. its a scheduling database
    4. numerical database
    5.
Correct Answer: 2.


Question 84: Homology Modelling server is

    1. SWISS-MODEL
    2. 3DPSSM
    3. Phyre
    4. Rosetta
    5.
Correct Answer: 4.


Question 85: B-oxidation of odd-chain fatty acids produces

    1. Succinyl CoA
    2. Propionyl CoA
    3. Acetyl CoA
    4. Malonyl CoA
    5.
Correct Answer: 2.


Question 86: Which of the following elements is the LEAST abundant in living organisms?

    1. oxygen
    2. nitrogen
    3. phosphorous
    4. sodium
    5.
Correct Answer: 4.


Question 87: Which of the following is true regarding hydroxyl ethyl starch

    1. It is an anesthetic agent
    2. It is a plasma expander
    3. It is a crystalloid
    4. Used as a nutritional agent
    5.
Correct Answer: 2.


Question 88: What is the type of Recombination vector generally recommended for HGP?

    1. Plasmid
    2. Cosmid
    3. BAC
    4. YAC
    5.
Correct Answer: 3.


Question 89: Fatty acids that are unsaturated have:

    1. an amino group
    2. a double bond
    3. an excess of protons
    4. a carboxyl group
    5.
Correct Answer: 2.


Question 90: ExPASY used for

    1. Nucleic acid analysis
    2. Protein sequence and structure analysis
    3. chemical analysis
    4. All
    5.
Correct Answer: 2.


Question 91: Basic amino acids are

    1. aspartate and glutamate
    2. serine and glycine
    3. lysine and arginie
    4.
    5.
Correct Answer: 3.


Question 92: Which components of Marvin Beans used for structure drawing

    1. Marvin Sketch
    2. Marvin View
    3. Marvin space
    4. All
    5.
Correct Answer: 1.


Question 93: Artificial Intelligence term is coined by.

    1. John McCarthy
    2. Watson
    3. Meselson
    4. George Mitchel
    5.
Correct Answer: 1.


Question 94: Transition temperature of lipid bilayers of cell membranes is increased by

    1. Cholesterol
    2. Saturated fatty acids
    3. Unsaturated fatty acids
    4. Hydrocarbons
    5.
Correct Answer: 2.


Question 95: How the fasta format file starts:

    1. begin
    2. >
    3. start
    4. entry
    5.
Correct Answer: 2.


Question 96: The primary defect which leads to sickle cell anemia is

    1. An abnormality in porphyrin part of hemoglobin
    2. Replacement of glutamate by valine in B-chain of HbA
    3. A nonsense mutation in the B-chain of HbA
    4. Substitution of valine by glutamate in the a-chain of HbA
    5.
Correct Answer: 2.


Question 97: Pathway prediction system of UM-BBD predicts pathway from

    1. SMILES
    2. structures
    3. Both
    4. None
    5.
Correct Answer: 1.


Question 98: Substrate level phosphorylation is seen in conversion of

    1. Acetoacetate to alpha keto glutarate
    2. Succinyl CoA to Succinate
    3. Fumarate to malate
    4. Succinate to fumarate
    5.
Correct Answer: 2.


Question 99: PDB stands for

    1. Public DNA Bank
    2. Protein Data Bank
    3. Protein DNA Bank
    4. All of the above
    5.
Correct Answer: 2.


Question 100: Handerson Hasselbach equation is for

    1. Electrolytes
    2. Acid base balance
    3. Fluid
    4. Enzymatic reaction
    5.
Correct Answer: 2.