Exam Paper : All India Institute of Medical Sciences M.D MD/MS Entrance Exam November 2005 University Question paper

26. Henoch-Schonlein purpura is characterized by the depositin of the following immunoglobulin around the vessels:
a) Ig M
b) Ig G
c) Ig A
d) Ig E

27. Angiod streaks in the eyes are seen in :
a) Pseudoxanthoma elasticum
b) Tendinous xanthoma
c) Xanthelasma
d) Eruptive xanthoma

28. Exclamation mark hair is a feature of:
a) Telogen effluvium
b) Andogenetic alopecia
c) Alopecia areata
d) Alpecia mucinosa

29. Pautrier's micro-abscess is a histological feature of:
a) Sarcoidosis
b) Tuberculosis
c) Mycosis fungoides
d) Pityriasis Lichenoides Chronica

30. Adenoma sebaceum is a feature of:
a) Neurofibromatosis
b) Tuberous sclerosis
c) Xanthomatosis
d) Incontinentia pigmenti

31. A 25 year old male presented with pigmentation of nose and pinna. After voiding, his urine becomes dark. His spine is most likely to show:
a) Atlantoaxial subluxation
b) Spondyloptosis
c) Basilar invagination
d) Calcification of disc

32. A one year old child presented with multiple fractures seen in various stages of healing. The most probable diagonis in this case is:
a) Scurvy
b) Rickets
c) Battered baby syndrome
d) Sickle cell disease

33. A 50 year old man presented with multiple pathological fractures. His serum calcium was 11.5mg/dl and phosphate was 2.5 mg/dl. Alkaline phosphatase was 940 I.U./dl. The most probable diagnosis is:
a) Osteoporosis
b) Osteomalacia
c) Multiple Myeloma
d) Hyperparathyrodism

34. Pain and tenderness over the lateral condyle of humerous with a painful dorsi flexion of the wrist is indicative of:
a) Golfer's Elbow
b) Tennis Elbow
c) Pitcher's Elbow
d) Cricket Elbow

35. The pain around the hip with flexion adduction & internal rotation of lower limb in a young adult after a road traffic accident is suggestive of:
a) Intracapsular fracture of the femoral neck.
b) Extra capsular fracture of the femoral neck.
c) Posterior disclocation of hip.
d) Anterior dislocation of hip

36. The inheritance pattern of familial Retinoblastomas is:
a) Autosomal recessive
b) Autosomal dominant
c) X-linked dominant
d) X-linked recessive

37. The lymphocytic and histiocytic variant of Reed-Sternberg cell is seen in:
a) Follicular center lymphoma
b) Lymphocyte depleted Hodgkin's disease
c) Nodular sclerosis Hodgkin's disease
d) Lymphocyte predominant Hodgkin's disease

38. A metastatic carcinoma in the brain of an adult, most often comes from a primary in the :
a) Stomach
b) Ovary
c) Oral cavity
d) Lung

39. Features, which are evaluated for histological grading of breast carcinoma include all of the following except:
a) Tumour necrosis
b) Mitotic count
c) Tubule formation
d) Nuclear pleomorphism

40. Internucleosomal cleavage of DNA is characteristic of:
a) Reversible cell injury
b) Irreversible cell injury
c) Necrosis
d) Apoptosis

41. Which of the following is not a common site for metastatic calcification?
a)Gastric mucosa
b) Kidney
c) Parathyroid
d) Lung

42. On electron microscopy, amyloid characteristically exhibits:
a) B-pleated sheat
b) Hyaline globules
c) 7.5-10nm fibrils
d) 20-25 nm fibrils

43. Which of the following is not compaitible with a diagnosis of juvenile myelemonocytic leukemia?
a) Peripharal blood monocytosis, more than 1x109/L
b) Increased of bcr/abl fusion gene
c) Presence of bcr/abl fusion gene.
d) GM-CSF hypersensitivity of myeloid progenitors in vitro.

44. A 48 year old woman was admitted with a history of weakness for two months. On examination, cervical lympth nodes were found enlarged and spleen was palpable 2 cm below the costal margin. Her hemoglobin was 10.5g/dl, platelet count 237 x 109/L, which included 80% mature lymphoid cells with coarse clumped chromatin. Bone marrow revealed a nodula lymphoid infiltrate. The peripheral blood lymphoid cells were positive for CD19, CD5, CD20 and CD23 and were negative for CD79B and FMC-7.

What is the most likely diagnosis?
a) T-cell rich B-cell lymphoma with leukemic spill over in blood.
b) Chronic lymphocytic leukemia
c) Mantle cell lymphoma
d) A definite diagnosis cannot be made in this patient without lymph node biopsy.

45. All of the following are examples of a round cell tumor, except:
a) Neuroblastoma
b) Ewing's sarcoma
c) Non Hodgkin,s Lymphoma
d) Osteosarcoma

46. Which of the following surface glycoproteins is most often expressed in human hematopoietic stem cell?
a) CD22
b) CD40
c) CD15 `
d) CD34

47. The tumor suppressor gene p53 induces cell cycle arrest at:
a) G2-M phase
b) S-G2 phase
c) G1-phase
d) G0 phase
48. During which phase of the cell cycle the cellular content of DNA is doubled?
a) Mitotic phase
b) G1 phase
c) G2 phase
d) S phase

49. Acute diffuse proliferative glomerulonephritis will have all of the following features, except:
a) Microscopic haematuria
b) Raised blood urea level
c) Raised serum creatinine level
d) Hypoalbuminaemia

50. All of the following are mediators of acute inflammation except:
a) Angiotensin
b) Prostaglandin E2
c) Kallikrein
d) C3a

51. A 50 year old male feels uncomfortable in using lift, being in crowded places and traveling. The most appropriate line of treatment is:
a) Counselling
b) Relaxation theraphy
c) Exposure
d) Covert sensitization

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